Rob Pincus is on the range with a Ruger 10/22, one of the most popular guns in the history of American firearms. The .22 Magnum version is a viable choice for home defense when loaded with proper ammunition, like the Winchester PDX1 round. Normally Rob wouldn’t recommend a .22 Magnum for personal defense, but for some shooters, it may be the perfect choice. The potential wounding factor of the .22 Magnum round is similar to a .380 and it has better penetration capabilities. And because the 10/22 is a semi-auto rifle, you can fire many rounds quickly and under control.